Osamu Kozawa Selected Research

Catechin (Z 7300)

6/2011	Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases.
8/2009	(-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts.
4/2007	(--)-epigallocatechin gallate enhances prostaglandin F2alpha-induced VEGF synthesis via upregulating SAPK/JNK activation in osteoblasts.

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Osamu Kozawa Research Topics

Disease

22	Neoplasms (Cancer) 10/2023 - 11/2005
21	Hepatocellular Carcinoma (Hepatoma) 10/2023 - 11/2005
10	Pancreatic Neoplasms (Pancreatic Cancer) 07/2016 - 06/2010
8	Glioma (Gliomas) 01/2016 - 07/2008
7	Bone Resorption 01/2023 - 04/2004
7	Colonic Neoplasms (Colon Cancer) 02/2013 - 10/2008
7	Thrombosis (Thrombus) 07/2010 - 01/2002
5	Carcinogenesis 02/2013 - 09/2009
4	Osteoporosis 12/2020 - 01/2002
4	Ischemia 10/2014 - 10/2002
4	Rheumatoid Arthritis 10/2013 - 04/2004
3	Diabetes Mellitus 11/2022 - 08/2009
3	Stroke (Strokes) 03/2020 - 11/2009
3	Vascular System Injuries 07/2004 - 11/2003
2	Peripheral Nervous System Diseases (PNS Diseases) 10/2023 - 10/2021
2	Bone Fractures (Bone Fracture) 01/2023 - 01/2021
2	Cerebral Hemorrhage 01/2022 - 01/2017
2	Type 2 Diabetes Mellitus (MODY) 01/2022 - 05/2016
2	Postmenopausal Osteoporosis 01/2022 - 01/2022
2	Low Back Pain (Lumbago) 12/2020 - 08/2020
2	Chronic Pain 12/2020 - 08/2020
2	Cardiovascular Diseases (Cardiovascular Disease) 03/2020 - 10/2002
2	Hypoxia (Hypoxemia) 02/2016 - 09/2006
2	Venous Thrombosis (Deep-Vein Thrombosis) 01/2016 - 01/2002
2	Inflammation (Inflammations) 06/2015 - 01/2015
2	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2014 - 11/2009
2	Colorectal Neoplasms (Colorectal Cancer) 07/2012 - 06/2011
2	Retinoblastoma (Glioblastoma, Retinal) 07/2011 - 03/2010
2	Hypercholesterolemia 08/2006 - 07/2004
2	Myocardial Infarction 06/2005 - 10/2002
2	Ganglion Cysts (Ganglion) 10/2004 - 10/2002
1	Dementia (Dementias) 01/2024
1	Pain (Aches) 10/2023
1	Atrophy 11/2022
1	Alzheimer Disease (Alzheimer's Disease) 01/2022

Drug/Important Bio-Agent (IBA)

17	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2017 - 01/2002
16	Proteins (Proteins, Gene)FDA Link 11/2022 - 07/2004
12	p38 Mitogen-Activated Protein KinasesIBA 10/2023 - 06/2005
10	Interleukin-6 (Interleukin 6)IBA 01/2023 - 04/2004
10	Phosphotransferases (Kinase)IBA 01/2021 - 09/2009
10	ErbB Receptors (EGF Receptor)IBA 12/2011 - 10/2008
8	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2023 - 04/2015
7	JNK Mitogen-Activated Protein KinasesIBA 10/2023 - 03/2010
7	CytokinesIBA 01/2023 - 04/2004
7	MitogensIBA 01/2021 - 06/2005
7	HSP27 Heat-Shock ProteinsIBA 03/2016 - 11/2005
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013 - 04/2004
5	rho-Associated KinasesIBA 01/2021 - 11/2009
5	Gemcitabine FDA Link 03/2016 - 10/2011
5	Epidermal Growth Factor (EGF)IBA 07/2011 - 10/2008
4	Protein Kinase CIBA 01/2021 - 07/2008
4	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA 01/2016 - 06/2009
4	InterleukinsIBA 01/2016 - 03/2010
4	Protein Kinases (Protein Kinase)IBA 10/2014 - 03/2010
4	TeaIBA 06/2011 - 04/2007
3	Duloxetine Hydrochloride (Cymbalta)FDA Link 10/2023 - 12/2020
3	OsteoprotegerinIBA 01/2023 - 01/2017
3	Small Heat-Shock ProteinsIBA 12/2022 - 01/2016
3	Platelet-Derived Growth FactorIBA 07/2016 - 06/2005
3	Becaplermin (PDGF-BB)FDA Link 07/2016 - 06/2005
3	CollagenIBA 01/2015 - 08/2009
3	Serine (L-Serine)FDA Link 11/2011 - 07/2008
3	Catechin (Z 7300)IBA 06/2011 - 04/2007
3	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 09/2009 - 10/2008
3	Retinaldehyde (Retinal)IBA 09/2006 - 10/2002
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2004 - 10/2002
3	Fibrinolysin FDA Link 11/2003 - 01/2002
3	Plasminogen Activator Inhibitor 1IBA 07/2003 - 02/2002
2	Amyloid (Amyloid Fibrils)IBA 11/2022 - 01/2022
2	Selective Estrogen Receptor Modulators (SERM)IBA 01/2022 - 01/2022
2	Raloxifene Hydrochloride (Evista)FDA Link 01/2022 - 01/2008
2	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2022 - 01/2021
2	Hormones (Hormone)IBA 01/2022 - 01/2022
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 10/2021 - 12/2020
2	Serotonin (5 Hydroxytryptamine)IBA 10/2021 - 12/2020
2	Olive OilIBA 03/2020 - 07/2019
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2020 - 01/2018
2	PolyphenolsIBA 07/2019 - 08/2009
2	LipidsIBA 01/2018 - 10/2008
2	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2017 - 01/2013
2	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2016 - 10/2014
2	Factor Xa (Coagulation Factor Xa)IBA 01/2016 - 07/2003
2	Midazolam (Versed)FDA LinkGeneric 01/2014 - 06/2011
2	Tissue Inhibitor of Metalloproteinase-1IBA 02/2013 - 01/2013
2	Mitogen-Activated Protein KinasesIBA 01/2013 - 11/2011
2	tyrosine receptor (receptor, tyrosine)IBA 07/2012 - 06/2011
2	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 06/2012 - 06/2009
2	Cyclin D1IBA 07/2011 - 03/2010
2	Y 27632IBA 01/2011 - 03/2010
2	NF-kappa B (NF-kB)IBA 03/2010 - 06/2009
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 08/2006 - 03/2004
1	Insulin (Novolin)FDA Link 01/2024
1	RANK LigandIBA 01/2023
1	Oncostatin MIBA 01/2023
1	Estrogens (Estrogen)FDA Link 01/2022
1	Estrogen ReceptorsIBA 01/2022
1	bazedoxifeneIBA 01/2022

Therapy/Procedure

7	Therapeutics 10/2013 - 01/2002
4	Drug Therapy (Chemotherapy) 10/2023 - 12/2011
2	Intravitreal Injections 09/2006 - 10/2004